Available in strips of 10 tablets, with typical retail price ₹ 232.30 per strip in India
Brand Overview & Composition
Cefolac‑O 200 mg tablet is manufactured by Macleods Pharmaceuticals (India). It combines two antibiotics:
- Cefixime 200 mg: a third‑generation cephalosporin
- Ofloxacin 200 mg: a fluoroquinolone antibiotic
Product introduction
Cefolac-O 200 Tablet is a prescription medicine. It is advised to take it as per the prescription. It can be taken with or without food, but it must be taken at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine.
Some common side effects of this medicine are nausea, vomiting, diarrhea, indigestion, etc. If any of the side effects get aggravated, you must consult your doctor immediately. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.
Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Pregnant or breastfeeding women should also consult with their doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. You must take adequate rest for a faster recovery, also take a healthy diet and drink plenty of water. Your doctor may ask for a few laboratory and diagnostic tests to know the effects of the medicine on your body.
Some common side effects of this medicine are nausea, vomiting, diarrhea, indigestion, etc. If any of the side effects get aggravated, you must consult your doctor immediately. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.
Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Pregnant or breastfeeding women should also consult with their doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. You must take adequate rest for a faster recovery, also take a healthy diet and drink plenty of water. Your doctor may ask for a few laboratory and diagnostic tests to know the effects of the medicine on your body.
Uses of Cefolac-O Tablet
Benefits of Cefolac-O Tablet
Treatment of Bacterial infections
Cefolac-O 200 Tablet is a combination of two different antibiotics that work together, in different ways, to treat various bacterial infections. Cefixime works by stopping the growth of bacteria and kills them. Ofloxacin prevents multiplication and repair of infection causing bacteria and prevents further spread of the infection.
This combination medicine can be used to treat many different bacterial infections such as ear, sinus, throat, lung, urinary tract, skin and soft tissues. It usually makes you feel better within a few days, but you should continue taking it as prescribed even when you feel better to make sure that all bacteria are killed and do not become resistant.
Cefolac-O 200 Tablet is a combination of two different antibiotics that work together, in different ways, to treat various bacterial infections. Cefixime works by stopping the growth of bacteria and kills them. Ofloxacin prevents multiplication and repair of infection causing bacteria and prevents further spread of the infection.
This combination medicine can be used to treat many different bacterial infections such as ear, sinus, throat, lung, urinary tract, skin and soft tissues. It usually makes you feel better within a few days, but you should continue taking it as prescribed even when you feel better to make sure that all bacteria are killed and do not become resistant.
How to use Cefolac-O Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cefolac-O 200 Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Cefolac-O Tablet works
Cefolac-O 200 Tablet is a combination of two antibiotics: Cefixime and Ofloxacin. Cefixime works by preventing the formation of the bacterial protective covering which is essential for the survival of the bacteria in the human body. Ofloxacin works by preventing the bacteria from reproducing and repairing themselves. Together, they treat your infection effectively.
Therapeutic Indications (Uses)
Cefolac‑O is used to treat mixed or uncertain bacterial infections, leveraging dual coverage from cefixime and ofloxacin:
• Respiratory tract infections: such as bronchitis and pneumonia caused by bacteria like Streptococcus pneumoniae and Haemophilus influenzae
• Urinary tract infections (UTIs): both uncomplicated and complicated cases (e.g. E. coli, Klebsiella)
• Skin and soft tissue infections: cellulitis, wound infections, abscesses
• Gastrointestinal infections: certain bacterial gastroenteritis
• Sexually transmitted infections: such as gonorrhea, especially where single‑drug therapy may fail
• Typhoid fever: sometimes used in community settings alongside other therapies
Dosage & Administration
• Adults: typically prescribed for 7–14 days, depending on infection type and severity
• Pediatric use: only under medical supervision; dosing based on weight and indication.
• Tablets should be swallowed whole with water, preferably after meals to minimize gastric upset. Do not crush or chew
• Missed dose: take as soon as remembered unless it’s nearly time for next dose. Do not double doses
• Storage: Store in a dry, cool place away from children; below 25 °C is advisable.
Side Effects & Adverse Reactions
Common Side Effects
• Gastrointestinal: diarrhea, nausea, vomiting, abdominal pain, indigestion, flatulence
• Headache, dizziness, dry mouth, weakness, occasionally photosensitivity from ofloxacin
Less Common / Serious Reactions
• Allergic reactions: rash, itching, urticaria, swelling, anaphylaxis → stop immediately and seek medical help
• Pseudomembranous colitis (C. difficile): severe diarrhoea reported; requires prompt discontinuation
• Hematologic changes: thrombocytopenia, eosinophilia, leukopenia; monitor counts if used long term
• CNS effects: seizures, insomnia, confusion—particularly from ofloxacin or in those with psychiatric history
• Tendinitis/tendon rupture: rare but known risk with fluoroquinolones like ofloxacin, especially elderly or concurrent corticosteroid use; report tendon pain promptly
• Photosensitivity: increased sunburn risk; use sunscreen or protective clothing
• Liver & renal caution: dose adjustments recommended if dysfunction is present
Contraindications & Special Precautions
• Contraindicated in individuals allergic to cephalosporins or fluoroquinolones
• Avoid in pregnancy: Cefixime alone may be safe, but combination is not recommended due to ofloxacin’s fetal risks
• Not advised during breastfeeding unless benefits outweigh risks; consult physician
• Use with caution in renal or hepatic impairment; may require dose adjustment or alternate therapy
• Photosensitivity risk: patients should avoid UV exposure and tanning lamps, particularly due to ofloxacin component
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Drug Interactions
• Probenecid: may raise blood levels of cefixime and ofloxacin
• Anticoagulants (e.g. warfarin): combination may prolong prothrombin time → monitor INR carefully
• Carbamazepine: ofloxacin may increase its plasma concentration → monitor levels and dosing
• Antacids containing magnesium, aluminum, calcium, or supplements with iron or zinc: can impair absorption of ofloxacin; space out dosing by ≥2 hours
• Corticosteroids: concurrent use may elevate risk of tendon complications
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Resistance & Stewardship Considerations
• Antibiotic combination should be used judiciously—preferably based on culture and sensitivity reports.
• Encourage patients to complete the full prescribed course, even if symptoms improve early, to prevent resistance or relapse
• Emphasize that antibiotics do not treat viral infections such as colds or influenza.
Practical Advice for Patients
• Take with food to reduce stomach upset.
• Avoid alcohol during therapy, as it may increase drowsiness and gastrointestinal upset
• Avoid excessive sun exposure; wear protective clothing and sunscreen.
• If experiencing tendon pain or joint discomfort, especially in ankles or wrists, contact your physician immediately.
• Monitor for persistent or bloody diarrhoea, rash, breathing difficulty, liver or kidney warning symptoms (e.g. jaundice, dark urine).
• Do not drive or operate heavy machinery if drowsiness, dizziness, or vision changes occur.
• Interactions with lab tests: may interfere with results like prothrombin/INR or glucose tests; inform healthcare providers about medication use.
Quick tips
- You have been prescribed Cefolac-O 200 Tablet to cure your infection and improve your symptoms.
- Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat.
- Take it with food to avoid an upset stomach.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
- Discontinue Cefolac-O 200 Tablet and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
- Notify your doctor if you feel pain in your tendons, numbness, or tingling sensations.
- Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
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