Cefolac 100 mg Tablet

 Cefolac DT-100 Tablet is an antibiotic belonging that is used to treat a variety of bacterial infections. It is effective in infections of the respiratory tract (eg. pneumonia), urinary tract, ear, nasal sinus, throat, and some sexually transmitted diseases.

Available in strips of 10 tablets, with typical retail price ₹ 109.80 per strip in India

General Information

Contains -   Cefixime (100mg)

Marketer-   Macleods Pharmaceuticals Pvt Ltd

Storage-       Store below 25°C

Product introduction

Cefolac DT-100 Tablet should be given under the supervision of a doctor or health professional. Use it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Using it at the same time every day will help you remember to take it. The dose will depend on what you are being treated for, but you should always complete the full course of this antibiotic as prescribed by your doctor. Do not stop taking it until you have finished, even when you feel better. If you stop taking it early, some bacteria may survive and the infection may come back or worsen. It will not work for viral infections such as flu or common cold. Using any antibiotic when you do not need it can make it less effective for future infections.

The most common side effects of this medicine include nausea, stomach pain, indigestion, and diarrhea. These are usually mild but let your doctor know if they bother you or do not go away.

Before taking it, you should let your doctor know if you are allergic to any antibiotics or have any kidney or liver problems. You should also let your healthcare team know all other medicines you are taking as they may affect, or be affected by this medicine. This medicine is generally regarded as safe to use during pregnancy and breastfeeding if prescribed by a doctor.

Uses of Cefolac Tablet DT

• Treatment of Bacterial infections

Benefits of Cefolac Tablet DT

Treatment of Bacterial infections
Cefolac DT-100 Tablet is an antibiotic medicine that works by killing the infection-causing bacteria in your body. It is effective for bacterial infections of the lungs, throat, and urinary tract among others. This medicine usually makes you feel better within a few days, but you should continue taking it as prescribed even when you feel better. Stopping it early may make the infection come back and harder to treat.

Side effects of Cefolac Tablet DT

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Cefolac

• Nausea
• Stomach pain
• Indigestion
• Diarrhea

How to use Cefolac Tablet DT

Take this medicine in the dose and duration as advised by your doctor. Dissolve it in a glass of water before taking it. Cefolac DT-100 Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Cefolac Tablet DT works

Cefolac DT-100 Tablet is an antibiotic. It kills the bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.

Cefolac 100 DT Tablet is a dispersible formulation of Cefixime, a third‑generation cephalosporin antibiotic widely used to treat various bacterial infections. The “DT” indicates it is a dispersible tablet—meaning it dissolves in water before administration, making it easy to take, especially for children and those who have difficulty swallowing.

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 Composition & Mechanism of Action

• Active Ingredient: Cefixime 100 mg

• Class: Third‑generation cephalosporin antibiotic

• Mechanism: It inhibits bacterial cell wall synthesis by binding to penicillin‑binding proteins, disrupting peptidoglycan cross-linking. This weakens and ultimately destroys susceptible bacteria .

Cefixime exhibits bactericidal activity against many Gram‑positive and Gram‑negative pathogens.

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Indications & Therapeutic Uses

Cefolac 100 DT is commonly prescribed for:

• Upper & lower respiratory tract infections (e.g. tonsillitis, pharyngitis, bronchitis, pneumonia)

• Urinary tract infections (cystitis, mild kidney infections)

• Otitis media (middle‑ear infection)

• Sinusitis

• Gonococcal infections (uncomplicated gonorrhoea)

• Skin and soft tissue infections and dental infections

• Occasionally used for typhoid fever management .

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Dosage & Administration

• Form: Dispersible tablet (DT).

• Adults & children over 12 or ≥50 kg: Typically 100 mg once a day or divided into two doses as per physician’s instruction.

• Children under 50 kg: Weight-adjusted dosing (e.g. ~8 mg/kg/day) generally up to 100 mg daily.

• Duration: Standard course is 7–14 days depending on the infection’s severity.

Administration Notes:

• Disperse each tablet in a small glass of water and consume immediately.

• Swallow with water—do not chew or crush .

• May be taken with or without food, though absorption might be modestly altered 

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Pharmacokinetics

• Absorption: Oral bioavailability ~40–50%. Food may delay T_max by ~0.8 hours but does not significantly reduce absorption 

• Peak serum levels: Within ~2–3 hours (onset) 

• Half-life: ~3–4 hours in normal renal function; prolonged up to ~9–11.5 hours in severe renal impairment (CrCl <20 mL/min) 

• Elimination: Primarily renal, unchanged in urine (~40–50% excreted). Faecal excretion accounts for remainder 

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 Side Effects

Common (generally mild and self‑limiting):

• Gastrointestinal: diarrhea, nausea, vomiting, abdominal pain, dyspepsia, flatulence 

• CNS: headache, dizziness 

Less common or rare but serious:

• Skin rash, pruritus, urticaria, swelling (face/lips/tongue), possible anaphylaxis 

• Altered taste, fungal infections (oral or vaginal), agitation, insomnia, confusion, nightmares, hallucinations, depression, anxiety 

• Severe: tendon inflammation or rupture, hemolytic anemia, renal or liver dysfunction, Stevens‑Johnson syndrome, DRESS 

• Clostridium difficile-associated diarrhea: severe, persistent diarrhea with blood, fever, cramps—potentially serious; discontinue and consult a doctor 

Patients should immediately stop the drug and seek medical help if allergic symptoms or severe gastrointestinal effects occur.

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Contraindications & Precautions

Contraindications

• Known allergy to Cefixime, other cephalosporins, or penicillins 

• Children under 6 months (safety not established) 

Precautions

• History of Gastrointestinal disease, especially colitis 

• Renal impairment: dose adjustment needed if creatinine clearance <20 mL/min; half‑life prolonged 

• Liver disease, seizure disorders: use with caution 

• Hemorrhagic disorders / anticoagulant therapy: may prolong prothrombin time, bleeding risk increased 

• Avoid alcohol or heavy machinery if dizziness or CNS effects occur.

Use in Special Populations

• Pregnancy (Category B): No adequate controlled human data; use if clearly needed 

• Breastfeeding: Unknown if excreted in human milk; use only if benefits outweigh risks 

• Elderly: No dose adjustment needed unless impaired renal function 

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 Drug Interactions

• Anticoagulants (e.g. warfarin): may increase prothrombin time and bleeding risk 

• Carbamazepine: plasma levels may rise when co-administered 

• Probenecid: can increase Cefixime plasma concentration by reducing renal tubular secretion 

• Nifedipine: may enhance bioavailability mildly 

• Live cholera vaccine: efficacy reduced if given within 14 days of antibiotic use 

Always inform your doctor of co‑administered medications.

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Overdose & Missed Dose

• Overdose symptoms: nausea/vomiting, severe diarrhea, abdominal pain, possible seizures, hematuria 

• If overdose is suspected, seek immediate medical attention.

• Missed dose: Take as soon as remembered. If close to next dose, skip; do not double up

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 Storage & Handling

• Store in a cool, dry place at temperature between 10 °C to 25 °C (below 30 °C), away from heat and sunlight

• Keep out of reach of children.

• Use within expiry; check integrity before

Quick tips

• Your doctor has prescribed Cefolac DT-100 Tablet to cure your infection and improve your symptoms.
• Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection harder to treat.
• Take it with food to avoid an upset stomach.
• Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
• Discontinue Cefolac DT-100 Tablet and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.