Zifi-O Tablet is a combination medicine that is used to treat various types of bacterial infections. It fights against the microorganisms to prevent their growth and further spread of the infection.
Introduction
Zofi O 200 Tablet is a combination antibiotic medication used to treat a variety of bacterial and parasitic infections. Each tablet typically contains Ofloxacin 200 mg and Ornidazole 500 mg, though some regional variants (such as “Zofi OF”) may contain Cefixime 200 mg, Ofloxacin 200 mg, and Lactobacillus spores. For this overview, we’ll focus on the common Ofloxacin + Ornidazole combination.
Available in strips of 10 tablets, with typical retail price ₹222.2 per strip in India
General Information
Contains :Cefixime (200mg)+ Ofloxacin (200mg)
Marketer :FDC Ltd
Storage :Store below 25°C
Product introduction
Zifi-O Tablet is a prescription medicine. It is advised to take it as per the prescription. It can be taken with or without food, but it must be taken at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine.
Some common side effects of this medicine are nausea, vomiting, diarrhea, indigestion, etc. If any of the side effects get aggravated, you must consult your doctor immediately. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.
Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Pregnant or breastfeeding women should also consult with their doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. You must take adequate rest for a faster recovery, also take a healthy diet and drink plenty of water. Your doctor may ask for a few laboratory and diagnostic tests to know the effects of the medicine on your body.
Some common side effects of this medicine are nausea, vomiting, diarrhea, indigestion, etc. If any of the side effects get aggravated, you must consult your doctor immediately. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.
Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Pregnant or breastfeeding women should also consult with their doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. You must take adequate rest for a faster recovery, also take a healthy diet and drink plenty of water. Your doctor may ask for a few laboratory and diagnostic tests to know the effects of the medicine on your body.
Uses of Zifi-O Tablet
Benefits of Zifi-O Tablet
Treatment of Bacterial infections
Zifi-O Tablet is a combination of two different antibiotics that work together, in different ways, to treat various bacterial infections. Cefixime works by stopping the growth of bacteria and kills them. Ofloxacin prevents multiplication and repair of infection causing bacteria and prevents further spread of the infection.
This combination medicine can be used to treat many different bacterial infections such as ear, sinus, throat, lung, urinary tract, skin and soft tissues. It usually makes you feel better within a few days, but you should continue taking it as prescribed even when you feel better to make sure that all bacteria are killed and do not become resistant.
Zifi-O Tablet is a combination of two different antibiotics that work together, in different ways, to treat various bacterial infections. Cefixime works by stopping the growth of bacteria and kills them. Ofloxacin prevents multiplication and repair of infection causing bacteria and prevents further spread of the infection.
This combination medicine can be used to treat many different bacterial infections such as ear, sinus, throat, lung, urinary tract, skin and soft tissues. It usually makes you feel better within a few days, but you should continue taking it as prescribed even when you feel better to make sure that all bacteria are killed and do not become resistant.
How to use Zifi-O Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zifi-O Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Zifi-O Tablet works
Zifi-O Tablet is a combination of two antibiotics: Cefixime and Ofloxacin. Cefixime works by preventing the formation of the bacterial protective covering which is essential for the survival of the bacteria in the human body. Ofloxacin works by preventing the bacteria from reproducing and repairing themselves. Together, they treat your infection effectively.
Composition & Mechanism of Action
• Ofloxacin (200 mg): A fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and repair, effectively killing susceptible bacteria.
• Ornidazole (500 mg): A nitroimidazole compound effective against anaerobic bacteria and certain protozoal infections. It disrupts microbial DNA by forming toxic intermediates.
Together, they offer broad-spectrum coverage against both aerobic bacteria and anaerobic pathogens such as Giardia and Entamoeba, making Zofi O especially effective in treating mixed infections like acute diarrhea, gastroenteritis, pelvic infections, and urinary or respiratory lung infections.
Therapeutic Uses
Zofi O 200 is prescribed for infections including but not limited to:
• Acute gastroenteritis, dysentery, and traveller’s diarrhea
• Urinary tract infections (e.g., cystitis, urethritis, prostatitis)
• Gynecological and post-operative pelvic infections
• Respiratory infections (bronchitis, pneumonia)
• Skin & soft tissue infections involving anaerobic bacteria
The dual-action ensures elimination of both bacterial pathogens and anaerobic/parasite organisms involved in polymicrobial infections.
Dosage & Administration
• How to take: Swallow tablets whole with water; do not chew, crush, or break. Typically taken with food to reduce gastrointestinal discomfort.
• Scheduling: Maintain fixed dosing intervals (e.g., every 12 hours) for consistent blood levels. Do not skip doses, and complete the full prescribed course—even if symptoms improve early—to prevent recurrence or resistance.
• Missed dose: If missed, take it as soon as you recall. Do not double up on doses.
Side Effects
Common (usually mild and transient):
• Nausea, vomiting, stomach pain, diarrhea, indigestion (dyspepsia), loss of appetite
• Dizziness, headache, insomnia, flatulence, dryness in mouth, itching or mild rash
Less common to rare (seek immediate attention):
• Tendon pain, swelling or rupture (especially Achilles tendon)
• Neurological symptoms: numbness, tingling, tremor, vertigo
• Severe skin reactions (e.g. rash, itching, Stevens‑Johnson syndrome)
• Psychiatric symptoms: anxiety, nightmares, confusion, hallucinations
• Signs of liver dysfunction: yellowing of skin/eyes, dark urine, abdominal pain
Precautions & Warnings
Allergy & Contraindications
• Do not use if allergic to Ofloxacin, Ornidazole, or related compounds. Seek immediate help if allergic symptoms arise (like swelling, rash, or breathing difficulty).
Drug Interactions
• Paracetamol: no documented adverse interaction, though consult your doctor before combining.
• Other drug interactions not listed here may exist—always disclose all current medications to your provider to minimize risk.
Managing Side Effects
• Gastrointestinal upset (nausea/vomiting): take with meals or milk; avoid heavy or spicy food; stay hydrated.
• Diarrhea: hydrate well; if persistent or bloody, contact your healthcare provider.
• Dizziness or headache: rest and hydrate; avoid critical tasks while affected.
• Skin rash or sensitivity: avoid sun exposure; wear sunscreen or protective clothing. Seek medical advice for worsening rash.
Conclusion
Zofi O 200 Tablet, combining Ofloxacin and Ornidazole, is a potent treatment for mixed aerobic-bacterial and anaerobic/parasitic infections. When used correctly—as directed by a healthcare provider—it is highly effective. However, caution is essential due to potential side effects, including gastrointestinal discomfort, neurological symptoms, tendon issues, and rare severe reactions. Avoid alcohol, ensure full course adherence, and consult your doctor if you are pregnant, breastfeeding, or have liver or kidney conditions.
Always consult a qualified healthcare professional before starting, altering, or stopping this treatment. The information above is for general knowledge and should not replace medical advice.
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Quick tips
You have been prescribed Zifi-O Tablet to cure your infection and improve your symptoms.
Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat.
Take it with food to avoid an upset stomach.
Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
Discontinue Zifi-O Tablet and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
Notify your doctor if you feel pain in your tendons, numbness, or tingling sensations.
Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
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